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Google Scholar profile Total citations: >3000. H-index: 26. i10-index: 31 (last checked Feb 2022)

Book Charpter

[1] Wang W, Qian F, and Montgomery RR. Age-Related Changes in Immune Regulation by Noncoding RNAs. Handbook of Immunosenescence. 2017; 1-18. ISBN: 978-3-319-64597-1.
[2] Qian F. Defining Innate Immune Pathways with Targeted RNAi Silencing. Experimental Approaches for the Investigation of Innate Immunity:The Human Innate Immunity Handbook. 2016; 65-75. ISBN: 978-981-4678-72-8.
[3] Qian F, and Montgomery RR. Imaging Immunosenescence. Immunosenescence: Methods and Protocols, Methods in Molecular Biology. 2015;1343:97-106. doi: 10.1007/978-1-4939-2963-4_8. [Pubmed]

Journal articles

*, co-first; ^#, corresponding

[1] Wu F, Han X, Liu J, Zhang Z, Yan K, Wang B, Yang L, Zou H, Yang C, Huang W, Jin L, Wang J#, Qian F#, Niu Z#. An ankylosing spondylitis risk variant alters osteoclast differentiation. Rheumatology (Oxford). 2022 Sep 19;keac542. doi: 10.1093/rheumatology/keac542.
[2] Tong Q, Liu H, Qi Q, Dai C, Yang T#, Qian F#. Development of a fully human anti-GITR antibody with potent antitumor activity using H2L2 mice. FEBS Open Bio. 2022 Jun 8. doi: 10.1002/2211-5463.13451.
[3] Sun Z, Song Z, Liu C, Tan S, Lin S, Zhu J, Dai F, Gao J, She J, Mei Z, Lou T, Zheng J, Liu Y, He J, Zheng Y, Ding C, Qian F, Zheng Y, Chen Y. Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients. BMC Med. 2022 Jan 20; 20(1):24. doi: 10.1186/s12916-021-02212-0.
[4] Cai Y, Wang J, Jin D, Liu Q, Chen X, Pan L, Li Y, Wang X, Qian F, Wang J, Zhong T, Wang S. Dhx15 regulates zebrafish definitive hematopoiesis through the unfolded protein response pathway. Cancer Sci. 2021 Sep;112(9):3884-3894. doi: 10.1111/cas.15002.
[5] Yang Y, Chai X, Xin W, Wang D, Dai C, Qian F#, Yang T#. Generation and characterization of a high-affinity chimeric anti-OX40 antibody with potent anti-tumor activity. FEBS Lett. 2021 Jun; 595(11):1587-1603. doi: 10.1002/1873-3468.14079.
[6] Li Z, Zhang W, Luo F, Li J, Yang W, Zhu B, Wu Q, Wang X, Sun C, Xie Y, Xu B, Wang Z, Qian F, Chen J, Wan Y, Hu W. Allergen-Specific Treg Cells Upregulated by Lung-Stage S. japonicum Infection Alleviates Allergic Airway Inflammation. Front Cell Dev Biol. 2021 Jun 8;9:678377. doi: 10.3389/fcell.2021.678377.
[7] Liu J, Tang Y, Huang Y, Gao J, Jiang S, Liu Q, Ma Y, Qian X, Qian F, Reveille JD, He D, Zou H, Jin L, Zhu Q, Pu W, Wang J. Single-cell analysis reveals innate immunity dynamics in ankylosing spondylitis. Clin Transl Med. 2021 Mar;11(3):e369. doi: 10.1002/ctm2.369.
[8] Wang R, Qian C, Pang Y, Li M, Yang Y, Ma H, Zhao M, Qian F, Yu H, Liu Z, Ni T, Zheng Y, Wang Y. opvCRISPR: One-pot visual RT-LAMP-CRISPR platform for SARS-cov-2 detection. Biosens Bioelectron. 2021 Jan 15; 172:112766. doi: 10.1016/j.bios.2020.112766. Epub 2020 Oct 26.[Pubmed]
[9] Chen Y, Zheng Y, Yu Y, Wang Y, Huang Q, Qian F (Co-first author), Sun L, Song Z, Chen Z, Feng J, An Y, Yang J, Su Z, Sun S, Dai F, Chen Q, Lu Q, Li P, Ling Y, Yang Z, Tang H, Shi L, Jin L, Holmes E, Ding C, Zhu T, Zhang Y. Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage. EMBO J. 2020 Nov 3; e105896. doi: 10.15252/embj.2020105896. [Pubmed]
[10] Chen Z, Li Z, Hu X, Xie F, Kuang S, Zhan B, Gao W, Chen X, Gao S, Li Y, Wang Y, Qian F, Ding C, Gan J, Ji C, Xu XW, Zhou Z, Huang J, He HH, Li J. Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation. Adv Sci (Weinh). 2020 Jun 8;7(14):2000532. doi: 10.1002/advs.202000532. [Pubmed]
[11] Abdulla A, Wang B, Qian F, Kee T, Blasiak A, Ong YH, Hooi L, Parekh F, Soriano R, Olinger GG, Keppo J, Hardesty CL, Chow EK, Ho D, Ding X. Project IDentif.AI: Harnessing Artificial Intelligence to Rapidly Optimize Combination Therapy Development for Infectious Disease Intervention. Adv Ther (Weinh). 2020 Apr 16:2000034. doi: 10.1002/adtp.202000034. [Pubmed]
[12] Zhou B, Qi F, Wu F, Nie H, Song Y, Shao L, Han J, Wu Z, Saiyin H, Wei G, Wang P, Ni T#, Qian F#. Endogenous Retroviruses Derived Long Non-coding RNA Enhances Innate Immune Responses via De-repressing RELA Expression. mBio. 2019 Jul 30; 10(4). pii: e00937-19. [Pubmed]
[13] Qi X, Jiao Y, Cheng C, Qian F, Chen Z, Wu Q. H22954, a novel long non-coding RNA down-regulated in AML, inhibits cancer growth in a BCL-2-dependent mechanism. Cancer Lett. 2019 Jul 10; 454:26-36.
[14] Zhou B, Wu F, Han J, Qi F, Ni T^#, Qian F^#.Exploitation of nuclear protein SFPQ by the encephalomyocarditis virus to facilitate its replication. Biochem Biophys Res Commun. 2019 Feb 26;510(1):65-71. doi: 10.1016/j.bbrc.2019.01.032. [Pubmed]
[15] Wu F, Niu Z, Zhou B, Li P, Qian F^#. PSMB1 Negatively Regulates the Innate Antiviral Immunity by Facilitating Degradation of IKK-ε.Viruses. 2019 Jan 24;11(2). pii: E99. doi: 10.3390/v11020099[Pubmed]
[16] Jin W, Lin D, Nguyen AH, Abdelrasoul GN, Chen J, Mar A, Qian F, Fang Q, Kovalchuk I, Wang Y, Chen J. Transfection of Difficult-to-Transfect Rat Primary Cortical Neurons with Magnetic Nanoparticles. J Biomed Nanotechnol. 2018 Sep 1; 14(9):1654-1664.[Pubmed]
[17] Li P, Jin Y, Qi F, Wu F, Luo S, Cheng Y, Montgomery RR, Qian F^#. SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-κB p65. Front Cell Infect Microbiol. 2018; 2018 Apr 9;8:113. doi: 10.3389/fcimb.2018.00113. [Pubmed]
[18] Wang X, Malawista A, Qian F, Ramsey C, Allore HG, Montgomery RR. Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes. Oncotarget. 2018; 9:9572-9580. [Pubmed]
[19] Pan L, Li Y, Zhang HY, Zheng Y, Liu XL, Hu Z, Wang Y, Wang J, Cai YH, Liu Q, Chen WL, Guo Y, Huang YM, Qian F, Jin L, Wang J and Wang SY., DHX15 is associated with poor prognosis in acute myeloid leukemia (AML) and regulates cell apoptosis via the NF-kB signaling pathway. Oncotarget. 2017 Aug 16;8(52):89643-89654 [Pubmed]
[20] Wang W*, Jin Y*, Zeng N, Ruan Q, Qian F ^#, SOD2 Facilitates the Antiviral Innate Immune Response by Scavenging Reactive Oxygen Species. Viral Immunol. 2017 Oct;30(8):582-589. [Pubmed]
[21] Ruan Q, Ruan J, Zhang W, Qian F, Yu Z., Jiucun Wang and Shao-yuan Wang, Targeting NAD+ degradation: The therapeutic potential of flavonoids for Alzheimer’s disease and cognitive frailty. Pharmacol Res. 2017 Aug 25. [Pubmed]
[22] Chu H, Jiang S, Liu Q, Ma Y, Zhu X, Liang M, Shi X, Ding W, Zhou X, Zou H, Qian F, Shaul PW, Jin L, Wang J, SIRT1 Protects Against Systemic Sclerosis-related Pulmonary Fibrosis by Decreasing Pro-inflammatory and Pro-fibrotic Processes. Am J Respir Cell Mol Biol. 2017 August 11. [Pubmed][23] Mark KMK, Varn FS, Ung MH, Qian F , Cheng C, The E2F4 prognostic signature predicts pathological response to neoadjuvant chemotherapy in breast cancer patients. BMC Cancer. 2017 May 2;17(1):306. [Pubmed]
[24] Liu Q, Chu H, Ma Y, Wu T, Qian F , Ren X, Tu W, Zhou X, Jin L, Wu W, Wang J, Salvianolic Acid B Attenuates Experimental Pulmonary Fibrosis through Inhibition of the TGF-β Signaling Pathway. Sci Rep. 2016 Jun 9;6:27610. [Pubmed]
[25] Ruan Q*, Qian F (Co-first author) , Yu Z., Effects of polymorphisms in immunity-related genes on the immune system and successful aging. Curr Opin Immunol. 2014 Apr; 29C:49-55. [Pubmed]
[26] Xu XH, Huang XW, Qun L, Li YN, Wang Y, Liu C, Ma Y, Liu QM, Sun K, Qian F, Jin L, Wang J., Two functional loci in the promoter of EPAS1 gene involved in high-altitude adaptation of Tibetans. Sci Rep. 2014 Dec 12; 4:7465. [Pubmed]

2007-2016 Yale Publications

[1] Qian F, Goel G, Meng H, Wang X, You F, Devine L, Raddassi K, Garcia MN, Murray KO, Bolen CR, Gaujoux R, Shen-Orr SS, Hafler D, Fikrig E, Xavier R, Kleinstein SH, Montgomery RR. Systems immunology reveals markers of susceptibility to West Nile virus infection. Clin Vaccine Immunol. 2015 Jan;22(1):6-16. [Pubmed]
[2] Qian F, Thakar J, Yuan X, Nolan M, Murray K, Lee W, Wong S, Meng H, Fikrig E, Kleinstein S, Montgomery RR., Immune Markers Associated with Host Susceptibility to Infection with West Nile Virus. Viral Immunology. 2014 Mar, 27(2): 39-47. [Pubmed]
[3] Qian F, Guo X, Wang X, Y uan X, Chen S, Malawista SE, Bockenstedt LK, Allore HG, Montgomery RR. Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging. Aging. 2014 Feb; 6(2):131-9. [Pubmed]
[4] Qian F, Chung L, Zheng W, Bruno V, Alexander RP, Wang Z, Wang X, Kurscheid S, Zhao H, Fikrig E, Gerstein M, Snyder M, Montgomery RR., Identification of genes critical for resistance to infection by West Nile virus using RNA-Seq analysis. Viruses. 2013 Jul 8; 5(7):1664-81. [Pubmed]
[5] Qian F, Bolen CR, Jing C, Wang X, Zheng W, Zhao H, Fikrig E, Bruce RD, Kleinstein SH, Montgomery RR. Impaired toll-like receptor 3-mediated immune responses from macrophages of patients chronically infected with hepatitis C virus. Clin Vaccine Immunol. 2013 Feb; 20(2):146-55. [Pubmed]
[6] Qian F, Wang X, Zhang L, Chen S, Piecychna M, Allore H, Bucala R, Fikrig E, Montgomery RR., Age-associated elevation in TLR5 leads to increased inflammatory responses in elderly. Aging Cell, 2012 Feb; 11(1):104-10. [Pubmed]
[7] Qian F, Montgomery RR., Quantitative imaging of lineage specific Toll-like receptor mediated signaling in monocytes and dendritic cells from small samples of human blood. J Vis Exp. 2012 Apr 16; (62). pii: 3741. doi: 10.3791/3741. [Pubmed]
[8] Qian F, Wang X, Zhang L, Lin A, Zhao H, Fikrig E, Montgomery RR., Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. J Infect Dis. 2011 May 15; 203(10):1415-24. [Pubmed]
[9] Panda A, Qian F (Co-first author), Mohanty S, van Duin D, Newman FK, Zhang L, Chen S, Towle V, Belshe RB, Fikrig E, Allore HG, Montgomery RR, Shaw AC. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol. 2010 Mar 1; 184(5):2518-27. [Pubmed]
[10] Das R, Loughran K, Murchison C, Qian F, Leng L, Song Y, Montgomery RR, Loeb M, Bucala R. Association between high expression macrophage migration inhibitory factor (MIF) alleles and West Nile virus encephalitis. Cytokine. 2016 Feb; 78: 51-4.[Pubmed]
[11] Tsioris K, Gupta NT, Ogunniyi AO, Zimnisky RM, Qian F, Yao Y, Wang X, Stern JN, Chari R, Briggs AW, Clouser CR, Vigneault F, Church GM, Garcia MN, Murray KO, Montgomery RR, Kleinstein SH, Love JC. Neutralizing antibodies against West Nile virus identified directly from human B cells by single-cell analysis and next generation sequencing. Integr Biol (Camb). 2015 Dec 30; 7(12):1587-97. [Pubmed]
[12] You F, Wang P, Yang L, Yang G, Zhao YO, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E. ELF4 is critical for induction of type I interferon and the host antiviral response. Nat Immunol. 2013 Dec; 14(12):1237-46. [Pubmed]
[13] Chung LM, Ferguson JP, Zheng W, Qian F, Bruno V, Montgomery RR, Zhao H., Differential expression analysis for paired RNA-Seq data. BMC Bioinformatics. 2013 Mar 27; 14:110. [Pubmed]
[14] Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E., IL-22 signaling contributes to West Nile encephalitis pathogenesis. PLoS One. 2012; 7(8):e44153. doi: 10.1371/journal.pone.0044153. Epub 2012 Aug 28. [Pubmed]
[15] Shaw AC, Panda A, Joshi SR, Qian F, Allore HG, Montgomery RR. Dysregulation of human Toll-like receptor function in aging. Ageing Res Rev. 2011 Jul; 10(3):346-53. [Pubmed]
[16] Cheng G, Cox J, Wang P, Krishnan MN, Dai J, Qian F, Anderson JF, Fikrig E. A C-Type Lectin Collaborates with a CD45 Phosphatase Homolog to Facilitate West Nile Virus Infection of Mosquitoes. Cell. 2010 Sep 3; 142(5):714-25. [Pubmed]
[17] Bai F, Kong KF, Dai J, Qian F, Zhang L, Brown CR, Fikrig E, Montgomery RR. A paradoxical role for neutrophils in the pathogenesis of West Nile virus. J Infect Dis. 2010 Dec 15; 202(12):1804-12. [Pubmed]
[18] Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, Fikrig E. IL-10 signaling blockade controls murine West Nile virus infection. PLoS Pathog. 2009 Oct; 5(10):e1000610. [Pubmed]
[19] Town T, Bai F, Wang T, Kaplan AT, Qian F, Montgomery RR, Anderson JF, Flavell RA, Fikrig E. Toll-like receptor 7 mitigates lethal West Nile encephalitis by affecting interleukin 23-dependent immune cell infiltration and homing. Immunity, 2009 Feb 20; 30(2):242-53. [Pubmed]
[20] Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E. RNA interference screen for human genes associated with West Nile virus infection. Nature, 2008 Sep 11; 455(7210):242-5. [Pubmed]
[21] Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR. Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J Virol. 2008 Aug; 82(15):7613-23. [Pubmed]
[22] Pedra JH, Sutterwala FS, Sukumaran B, Ogura Y, Qian F, Montgomery RR, Flavell RA, Fikrig E. ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection. J Immunol. 2007 Oct 1; 179(7):4783-91. [Pubmed]

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